Discovery and Designation of Type Specimens of Chrysomelidae (Coleoptera) From Argentina Described by E. von Harold in 1875

Type specimens of 14 species of Chrysomelidae from Cordova, Argentina. collected by W. M. Davis and described by E. von Harold in 1875, were discovered in the collections of the Museum of Comparative Zoology (Harvard University). A few specimens from some other museums such as the Museum für Naturkunde der Humboldt-Universität (Berlin), The Natural History Museum (London), Institut Royal des Sciences Naturelles de Belgique (Brussels), Museo Nacional de Hungaria (Budapest) are also apparently from the original series. Lectotypes and paralectotypes are designated for all species

Interleukin-10 negatively regulates local cytokine and chemokine production but does not influence antibacterial host defense during murine pneumococcal meningitis.

To determine the role of endogenous interleukin-10 (IL-10) in local host defense during pneumococcal meningitis, the inflammatory responses of IL-10-gene-deficient and wild-type mice after the induction of meningitis were compared. The absence of IL-10 was associated with higher cytokine and chemokine concentrations and a more pronounced infiltrate, but antibacterial defense or survival was not influenced

Smoking and Second Hand Smoking in Adolescents with Chronic Kidney Disease: A Report from the Chronic Kidney Disease in Children (CKiD) Cohort Study

The goal of this study was to determine the prevalence of smoking and second hand smoking [SHS] in adolescents with CKD and their relationship to baseline parameters at enrollment in the CKiD, observational cohort study of 600 children (aged 1-16 yrs) with Schwartz estimated GFR of 30-90 ml/min/1.73m2. 239 adolescents had self-report survey data on smoking and SHS exposure: 21 [9%] subjects had “ever” smoked a cigarette. Among them, 4 were current and 17 were former smokers. Hypertension was more prevalent in those that had “ever” smoked a cigarette (42%) compared to non-smokers (9%), p\u3c0.01. Among 218 non-smokers, 130 (59%) were male, 142 (65%) were Caucasian; 60 (28%) reported SHS exposure compared to 158 (72%) with no exposure. Non-smoker adolescents with SHS exposure were compared to those without SHS exposure. There was no racial, age, or gender differences between both groups. Baseline creatinine, diastolic hypertension, C reactive protein, lipid profile, GFR and hemoglobin were not statistically different. Significantly higher protein to creatinine ratio (0.90 vs. 0.53, p\u3c0.01) was observed in those exposed to SHS compared to those not exposed. Exposed adolescents were heavier than non-exposed adolescents (85th percentile vs. 55th percentile for BMI, p\u3c 0.01). Uncontrolled casual systolic hypertension was twice as prevalent among those exposed to SHS (16%) compared to those not exposed to SHS (7%), though the difference was not statistically significant (p= 0.07). Adjusted multivariate regression analysis [OR (95% CI)] showed that increased protein to creatinine ratio [1.34 (1.03, 1.75)] and higher BMI [1.14 (1.02, 1.29)] were independently associated with exposure to SHS among non-smoker adolescents. These results reveal that among adolescents with CKD, cigarette use is low and SHS is highly prevalent. The association of smoking with hypertension and SHS with increased proteinuria suggests a possible role of these factors in CKD progression and cardiovascular outcomes

An equilibrium model for RFP plasmas in the presence of resonant tearing modes

The equilibrium of a finite-beta RFP plasma in the presence of saturated-amplitude tearing modes is investigated. The singularities of the MHD force balance equation JXB=grad(p) at the modes rational surfaces are resolved through a proper regularization of the zeroth-order (equilibrium) profiles, by setting to zero there the gradient of the pressure and parallel current density. An equilibrium model, which satisfies the regularization rule at the various rational surfaces, is developed. The comparison with the experimental data from the Reversed Field eXperiment (RFX) gives encouraging results. The model provides an easy tool for magnetic analysis: many aspects of the perturbations can be analyzed and reconstructed.Comment: Final accepted version. 36 page

Cardiomyocyte-specific estrogen receptor alpha increases angiogenesis, lymphangiogenesis and reduces fibrosis in the female mouse heart post-myocardial infarction

Experimental studies showed that 17{beta}-estradiol (E2) and activated Estrogen Receptors (ER) protect the heart from ischemic injury. However, the underlying molecular mechanisms are not well understood. To investigate the role of ER{alpha} in cardiomyocytes in the setting of myocardial ischemia, we generated transgenic mice with cardiomyocyte-specific overexpression of ER-{alpha} (ER{alpha}-OE) and subjected them to Myocardial Infarction (MI). At the basal level, female and male ER{alpha}-OE mice showed increased Left Ventricular (LV) mass, LV volume and cardiomyocyte length. Two weeks after MI, LV volume was significantly increased and LV wall thickness decreased in female and male WT-mice and male ER{alpha}-OE, but not in female ER{alpha}-OE mice. ER{alpha}-OE enhanced expression of angiogenesis and lymphangiogenesis markers (Vegf, Lyve-1), and neovascularization in the peri-infarct area in both sexes. However, attenuated level of fibrosis and higher phosphorylation of JNK signaling pathway could be detected only in female ER{alpha}-OE after MI. In conclusion, our study indicates that ER{alpha} protects female mouse cardiomyocytes from the sequelae of ischemia through induction of neovascularization in a paracrine fashion and impaired fibrosis, which together may contribute to the attenuation of cardiac remodelling

Hyperimmunoglobulinemia D and periodic fever : A new syndrome

Contains fulltext : 4434.pdf (publisher's version ) (Open Access

Love Thy Neighbor As Thyself

[Verse 1] Our deacon went to town and at a swell hotel he stayed, When a man he never knew Said “I remember you,” Just entertain my wife tonight at work I’ll be delayed, But the landlord whispered, “Deacon, just be nice, And you’ll find it safe to follow this advice.” [Chorus 1] Love thy neighbor as thyself, but leave his wife alone, Or else that neighbor might get wise and try to win your own, So try to lead the simple life, but lead it with your own dear wife,Live thy neighbor as thyself, but leave his wife alone. [Verse 2] My friend next door went on a trip, his poor wife stayed behind, And I thought it was no crime To give her one good time, So I gave her a cute gold watch, the best time I could find, Making presents in his absence didn’t go, So her husband wrote me this to let me know. [Chorus 2] Love thy neighbor as thyself, but leave his wife alone, Or else that neighbor might get wise and try to win your own, With fifty men I’d trust my wife, but with just one, “not on your life,” Love thy neighbor as thyself, but leave his wife alone. [Verse 3] I went up in an aeroplane with Jonesey and his bride, So she would not be afraid My arm around her strayed, “Leave her alone or I will leave this lever go” he cried, “If I do it’s plain this aeroplane will fall,” Then he said some more but this much I recall. [Chorus 3] Love thy neighbor as thyself, but leave his wife alone, Or else that neighbor might get wise and try to win your own, I knew she wasn’t safe down there that’s why I brought her in the air, Love thy neighbor as thyself, but leave his wife alone. [Verse 4] A male and female on a fence were singing in B Flat It’s an ordinary thing, to hear two young cats sing, They sang the latest catalogue of catawauls and that When another Tom yelled “What is this I see? Quit my bride or there’ll be some catastrophy: [Chorus 4] Love thy neighbor as thyself, but leave his wife alone, Or else that neighbor might get wise and try to win your own, “I cant bring suit, I think it’s tough A back fence isn’t grounds enough Love thy neighbor as thyself, but leave his wife alone

Clinical infections and nonsurgical treatment of parapharyngeal space infections complicating throat infection

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Regulation of progesterone receptor signaling by BRCA1 in mammary cancer

Inherited mutations of the BRCA1 gene (chromosome 17q21), a tumor suppressor, lead to an increased risk of breast cancer, ovarian cancer, and several other hormone-responsive tumor types. Over the last ten years, BRCA1 has been found to play major roles in DNA damage signaling, repair, and cell cycle checkpoints. In addition, unfolding evidence suggests that BRCA1 functions as a co-regulator for steroid hormone receptors and modulates steroid hormone action. In this paper, we will briefly review this evidence and present a model to address the role of the progesterone and estrogen receptors in BRCA1 mutant mammary carcinogenesis. Finally, we will consider some of the clinical implications of this model

Study protocol: The Dutch 20|30 Postmeningitis study: a cross-sectional follow-up of two historical childhood bacterial meningitis cohorts on long-term outcomes

BACKGROUND: Bacterial meningitis (BM) is a serious, life-threatening infectious disease of the central nervous system that often occurs in young children. The most common severe to moderate sequelae following BM are sensorineural hearing loss, neuromotor disabilities and mental retardation, while subtle sequelae include academic and behavioral disabilities. It is largely unknown whether these more subtle sequelae persist into adolescence and adulthood. Therefore, this study will investigate the very long-term effects of childhood BM in later life. Better understanding of long-term effects and early identification of adverse outcomes after BM are essential for more timely interventions. Additionally, certain single nucleotide polymorphisms (SNPs) are associated with disease severity and might predict adverse sequelae. These include SNPs in genes encoding for pathogen recognition and immune response upon infection. Accordingly, a secondary objective of this study is to investigate the role of genetic variation in BM and use any insights to predict short- and long-term outcomes. METHODS: In the Dutch 20|30 Postmeningitis study, adolescents and young adults (n = 947) from two historical cohorts with a prior episode of BM during childhood will be enrolled into a cross-sectional follow-up investigation using mainly questionnaires that examine executive and behavioral functioning, health-related quality of life, subjective hearing, mood and sleeping disorders, academic performance, and economic self-sufficiency. The results will be compared to normative data by one-sample t-tests. Multivariable regression analysis will be used to assess for any associations with causative pathogens and severity of BM. Participants that complete the questionnaires will be approached to provide a swab for buccal DNA and subsequent sequencing analyses. Logistic regression models will be used to predict sequelae. DISCUSSION: The unique follow-up duration of this cohort will enable us to gain insights into the possible very long-term adverse effects of childhood BM and how these might impact on quality of life. The investigation of host genetic factors will contribute to the development of prediction models which will serve as prognostic tools to identify children who are at high risk of adverse outcome after BM. TRIAL REGISTRATION: Dutch Trial Register NTR-6891. Retrospectively registered 28 December 2017